The opioid epidemic in the United States has been highly influenced by the prevalence of fentanyl, a potent synthetic opioid. However, the dosing guidelines for buprenorphine and methadone, two commonly used medications for opioid use disorder (OUD), have not been adequately adjusted to account for the fentanyl era. Patients with a history of chronic fentanyl
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Metastatic uveal melanoma is a rare but devastating form of cancer. However, a bispecific T-cell receptor therapy called tebentafusp (Kimmtrak) has shown significant promise in improving overall survival for selected patients. In a phase III trial, tebentafusp demonstrated a clear survival benefit at 3 years, particularly among HLA-A*02:01-positive patients. These updated results, presented at the
Hypertension, or high blood pressure, is a common health condition that affects millions of individuals worldwide. Not only does hypertension pose a risk for various cardiovascular diseases, but recent research suggests that it may also impact the development of fibroids in midlife women. Fibroids, or uterine leiomyomas, are noncancerous growths that occur in the uterus
The management of acute kidney injury (AKI) in outpatient hemodialysis units presents unique challenges and opportunities. With the Advancing American Kidney Health Initiative making decreasing end-stage renal disease (ESRD) a national priority, increased attention to dialysis-requiring AKI (AKI-D) is critical. This article analyzes the current state of AKI-D management, identifies areas for improvement, and explores
The use of teplizumab (Tzield) in the treatment of type 1 diabetes (T1D) has shown promising results, according to the PROTECT trial. This randomized study demonstrated that early administration of teplizumab can help preserve beta-cell function and delay disease progression in individuals with T1D. Although the drug did not improve glucose control or reduce hypoglycemia
The arrival of long-acting injectable antiretroviral therapy (ART) has brought a new option for providers and patients with HIV. This innovative treatment offers an alternative to daily oral pills, which can be burdensome for some individuals. Long-acting ART provides convenience, reduces pill burdens, and may help prevent stigmatization. However, while this treatment option has shown
Blood transfusions are a common and critical intervention in the treatment of critically ill patients. However, determining the appropriate amount of blood to transfuse is often a complex decision with significant implications for patient outcomes. In a recent single-center study, Janet Adegboye, MD, of Johns Hopkins University, explored the relationship between hemoglobin levels and in-hospital
A groundbreaking revelation in the field of multiple sclerosis (MS) research suggests that a cure for this debilitating disease may be within reach. Renowned MS researcher, Stephen Hauser, MD, of the University of California San Francisco, discussed the potential for advancing from suppressing the disease to finding a cure during his keynote speech at the
Penicillin is one of the most common allergies reported by patients in their electronic health records (EHRs). However, recent research suggests that a significant portion of these patients may not truly be allergic to penicillin. In a quality-improvement project conducted at a community hospital, Dr. Ibrahim Shah and his colleagues aimed to explore methods of
Breast cancer is a significant health concern globally, and accurate prognosis estimation is crucial for effective treatment decisions. The PREDICT prognostication tool has been developed to estimate survival rates in breast cancer patients. A recent study conducted by researchers at Case Western Reserve University School of Medicine in Cleveland evaluated the accuracy of the PREDICT