A recent randomized trial has revealed that low-dose naltrexone does not provide any additional pain relief compared to a placebo in patients with fibromyalgia. This is a significant setback for the hopes that this opioid receptor antagonist could be an effective treatment for a condition that has thus far been difficult to manage. The trial,
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In a recent study presented at the annual meeting of the International Gynecologic Cancer Society, the antibody-drug conjugate trastuzumab deruxtecan (T-DXd; Enhertu) has shown promising response rates in heavily pretreated patients with HER2-expressing gynecologic cancers. Dr. Ritu Salani from the University of California Los Angeles highlights the significance of trastuzumab deruxtecan in the field of
Serial infusions have emerged as a potential solution in restoring amniotic fluid lost due to the lack of fetal renal development before 26 weeks’ gestation. This groundbreaking approach has significantly improved the rate of live births among cases of fetal bilateral renal agenesis, a condition that is otherwise uniformly lethal. The RAFT trial, which investigated
Myelodysplastic syndromes (MDS) pose a significant challenge in clinical management, particularly for patients with lower-risk disease who relapse or have refractory disease. The IMerge trial investigated the efficacy of imetelstat, a first-in-class telomerase inhibitor, in achieving red blood cell (RBC) transfusion independence in this patient population. The IMerge trial, led by Dr. Uwe Platzbecker and
The journey of becoming an oncologist is often one driven by personal experiences and a deep commitment to making a difference in the lives of cancer patients. For Dr. Emily Adams, this path was illuminated by her own battle with acute promyelocytic leukemia (APL) at the age of 24. In this article, we will delve
The so-called “Take Care of Maya” trial recently culminated in a shocking $261 million verdict, implicating Johns Hopkins All Children’s Hospital of Florida for a multitude of claims. Among them were charges of wrongful death, emotional distress, and false imprisonment. The Kowalski family asserted that the hospital inaccurately labeled Beata Kowalski as the perpetrator of
Medical professionals have long awaited breakthroughs in the treatment options for atopic dermatitis. As advancements in psoriasis treatments became increasingly promising, those focused on atopic dermatitis found themselves eagerly waiting for their turn. However, with the introduction of biologics in 2017, there was finally a glimmer of hope. While having one treatment option was a
Children under the age of 5 who are living with HIV face significantly higher mortality rates than their older counterparts, according to a study conducted by the CDC. The research reveals that children under the age of 1 receiving antiretroviral treatment (ART) had a mortality rate of 4.9%, while those between the ages of 1
In a small prospective cohort study conducted by Nico Sollmann, MD, of University Hospital Ulm in Germany, the link between inflammation and edema of the trapezius muscles and tension and migraine headaches was explored. The study found that patients with mixed-type tension and migraine headaches had the highest muscle T2 MRI values compared to those
In a recent presentation at the International Gynecologic Cancer Society annual meeting, Dr. Roisin O’Cearbhaill discussed the safety and efficacy of ubamatamab (REGN4018), an investigational bispecific antibody, in patients with recurrent ovarian cancer. The results of the phase I study showed that ubamatamab, either alone or in combination with the PD-1 inhibitor cemiplimab (Libtayo), demonstrated